Safe places
Once the game moves from afternoon to evening, you can unlock the option to send several NPCs to either Oedon Chapel or Iosefka's Clinic.
Oedon Chapel
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NPCs remain in the chapel, can be interacted with and change their dialog as time progresses.
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Rewards vary, but mainly consist of recovery consumables.
Iosefka's Clinic
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NPCs can no longer be interacted with.