NPC questlines
Dragonrot recovery
When Dragonrot first triggers, Sekiro will be transported back to Dilapidated Temple, and Sculptor will get sick, along with a random previously met NPC.
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Talk to Emma
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Rest and to her again
Inside the Dilapidated Temple.
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Acquire the blood sample and take it to Emma
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Rest and talk to her again
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Give Emma's Ashina Sake to the Sculptor
Decide Kotaro's fate
Once you've acquired the pinwheel(s), return to the start of the Senpou Temple area and give Kotaro:
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Use Divine Abduction on him
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Talk to him in Halls of Illusion
Red and White Pinwheel and send him to
Requires having advanced Anayama's questline to the point where he asks for an assistant.
See Anayama's questline for more details.
Requires having talked to Doujun in the Abandoned Dungeon.
See Doujun's questline for more details.
Help Hanbei the Undying
Hanbei wants to die, and once you've acquired Mortal Blade, you can grant his wish.
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Talk to him and agree
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Talk to him again and perform the execution